diff --git a/.changeset/empty-bats-grow.md b/.changeset/empty-bats-grow.md
new file mode 100644
index 000000000..4ad7871c9
--- /dev/null
+++ b/.changeset/empty-bats-grow.md
@@ -0,0 +1,5 @@
+---
+'@astrojs/markdown-remark': patch
+---
+
+Fix: HTML comments in markdown code blocks should not be wrapped in JS comments
diff --git a/packages/astro/src/vite-plugin-markdown/index.ts b/packages/astro/src/vite-plugin-markdown/index.ts
index ba749e249..2bcc0b241 100644
--- a/packages/astro/src/vite-plugin-markdown/index.ts
+++ b/packages/astro/src/vite-plugin-markdown/index.ts
@@ -141,6 +141,7 @@ export default function markdown({ config }: AstroPluginOptions): Plugin {
 
 				// Turn HTML comments into JS comments while preventing nested `*/` sequences
 				// from ending the JS comment by injecting a zero-width space
+				// Inside code blocks, this is removed during renderMarkdown by the remark-escape plugin.
 				markdownContent = markdownContent.replace(
 					/<\s*!--([^-->]*)(.*?)-->/gs,
 					(whole) => `{/*${whole.replace(/\*\//g, '*\u200b/')}*/}`
diff --git a/packages/astro/test/astro-markdown.test.js b/packages/astro/test/astro-markdown.test.js
index dd40bc071..0afbfdf36 100644
--- a/packages/astro/test/astro-markdown.test.js
+++ b/packages/astro/test/astro-markdown.test.js
@@ -79,6 +79,20 @@ describe('Astro Markdown', () => {
 		expect($('h1').text()).to.equal('It still works!');
 	});
 
+	it.only('Can handle HTML comments in inline code', async () => {
+		const html = await fixture.readFile('/comment-with-js/index.html');
+		const $ = cheerio.load(html);
+		
+		expect($('p code').text()).to.equal('<!-- HTML comments in code -->');
+	});
+
+	it('Can handle HTML comments in code fences', async () => {
+		const html = await fixture.readFile('/comment-with-js/index.html');
+		const $ = cheerio.load(html);
+
+		expect($('body > code').text()).to.equal('<!-- HTML comments in code fence -->')
+	});
+
 	// https://github.com/withastro/astro/issues/3254
 	it('Can handle scripts in markdown pages', async () => {
 		const html = await fixture.readFile('/script/index.html');
diff --git a/packages/astro/test/fixtures/astro-markdown/src/pages/comment-with-js.md b/packages/astro/test/fixtures/astro-markdown/src/pages/comment-with-js.md
index 387b8380e..374463d2d 100644
--- a/packages/astro/test/fixtures/astro-markdown/src/pages/comment-with-js.md
+++ b/packages/astro/test/fixtures/astro-markdown/src/pages/comment-with-js.md
@@ -14,4 +14,10 @@ function test() {
 ```
 -->
 
+```
+<!-- HTML comments in code fence -->
+```
+
+`<!-- HTML comments in code -->`
+
 # It still works!
diff --git a/packages/markdown/remark/src/index.ts b/packages/markdown/remark/src/index.ts
index 9dfc0e38c..7034564c3 100644
--- a/packages/markdown/remark/src/index.ts
+++ b/packages/markdown/remark/src/index.ts
@@ -6,6 +6,7 @@ import rehypeEscape from './rehype-escape.js';
 import rehypeExpressions from './rehype-expressions.js';
 import rehypeIslands from './rehype-islands.js';
 import rehypeJsx from './rehype-jsx.js';
+import remarkEscape from './remark-escape.js';
 import remarkMarkAndUnravel from './remark-mark-and-unravel.js';
 import remarkMdxish from './remark-mdxish.js';
 import remarkPrism from './remark-prism.js';
@@ -46,7 +47,7 @@ export async function renderMarkdown(
 	let parser = unified()
 		.use(markdown)
 		.use(isMDX ? [remarkMdxish, remarkMarkAndUnravel] : [])
-		.use([remarkUnwrap]);
+		.use([remarkUnwrap, remarkEscape]);
 
 	if (remarkPlugins.length === 0 && rehypePlugins.length === 0) {
 		remarkPlugins = [...DEFAULT_REMARK_PLUGINS];
diff --git a/packages/markdown/remark/src/remark-escape.ts b/packages/markdown/remark/src/remark-escape.ts
new file mode 100644
index 000000000..312bbe2cd
--- /dev/null
+++ b/packages/markdown/remark/src/remark-escape.ts
@@ -0,0 +1,17 @@
+import { visit } from 'unist-util-visit';
+import type { Literal } from 'unist';
+
+// In code blocks, this removes the JS comment wrapper added to
+// HTML comments by vite-plugin-markdown.
+export default function remarkEscape() {
+	return (tree: any) => {
+		visit(tree, 'code', removeCommentWrapper);
+		visit(tree, 'inlineCode', removeCommentWrapper);
+	};
+
+	function removeCommentWrapper(node: Literal<string>) {
+		node.value = node.value
+			.replace(/{\/\*<!--/gs, '<!--')
+			.replace(/-->\*\/}/gs, '-->');
+	}
+}
diff --git a/packages/markdown/remark/test/expressions.test.js b/packages/markdown/remark/test/expressions.test.js
index 2963ff7f1..12ddc1f48 100644
--- a/packages/markdown/remark/test/expressions.test.js
+++ b/packages/markdown/remark/test/expressions.test.js
@@ -79,4 +79,24 @@ describe('expressions', () => {
 
 		chai.expect(code).to.equal(`{frontmatter.list.map(item => <p id={item}>{item}</p>)}`);
 	});
+
+	it('should unwrap HTML comments in inline code blocks', async () => {
+		const { code } = await renderMarkdown(
+		`\`{/*<!-- HTML comment -->*/}\``
+		);
+
+		chai.expect(code).to.equal('<p><code is:raw>&lt;!-- HTML comment --&gt;</code></p>');
+	});
+
+	it('should unwrap HTML comments in code fences', async () => {
+		const { code } = await renderMarkdown(
+			`
+			  \`\`\`
+				<!-- HTML comment -->
+				\`\`\`
+			`
+		);
+
+	 chai.expect(code).to.match(/(?<!{\/\*)&lt;!-- HTML comment --&gt;(?!\*\/})/);
+	});
 });